Autophagy: Chapter 2. Selective Autophagy: Role of Interaction between the Atg8 Family Interacting Motif and Atg8 Family Proteins Book PDF, ePub eBook

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Book Descriptions:
Autophagy mediates the selective degradation of various targets, such as aggregated proteins, damaged or superfluous organelles, and invading microbes. Specific adaptors, also known as receptors, play a critical role in target recognition in autophagy. Almost all adaptors possess at least one Atg8 family interacting motif (AIM) that interacts directly with Atg8 family proteins, as a prerequisite for selective packaging of targets into autophagosomes. Recent studies have revealed not only the divergence of AIM sequences and their interaction with Atg8 family proteins, but also the regulation of the AIM–Atg8 interaction through phosphorylation.

Autophagy: Chapter 2. Selective Autophagy: Role of Interaction between the Atg8 Family Interacting Motif and Atg8 Family Proteins by Nobuo N. Noda, Fuyuhiko Inagaki

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